Endocrine Abstracts

Background: Peutz Jegher’s syndrome is a rare condition with substantial cancer risk. Testicular cancer risk is 9%, the commonest being pre-pubertal large cell Sertoli cell tumour (LCST) which usually presents with bilateral gynecomastia. Here we present a case of Peutz Jegher’s syndrome with LCST who presented with unilateral gynecomastia.Case: A 5-year-old boy was referred to our endocrine service with unilateral gynecomastia. He had right si...

Introduction: Congenital adrenal hyperplasia (CAH) varies significantly in clinical presentation and progression causing challenges in management. The ultimate goal of treatment is to achieve normal growth and development while avoiding adrenal crisis and hyperandrogenism.Aim: Our aim was to ascertain the current practice in the UK on CAH management in children and compare these with the endocrine society recommendations.Methods: A...

Background: Recent studies have reported a correlation between the increase in incidence of Type 1 Diabetes (T1DM) in children and young people (CYP) and SARS-COVID19 Infection.Aims and objectives: To study if there is an increase in TIDM incidence in CYP (aged 0-18yrs) post-covid19 (April 2020- March 2021) in East of England (EOE) region compared to previous years (April 2018- March 2020). To identify a correlation between T1DM incidence and the UK COVI...

Objectives: Glycaemic targets set by diabetes teams appear to have an impact on glycaemic control. Our objective was to identify if there is consensus between and within teams in our network on glycaemic targets and whether this correlates with HbA1c outcomes.Methods: An online survey was sent to all network members requesting an independent response on the diabetes self-management advice given to families. Three patient groups were considered: children ...

Sarcoidosis is a rare multisystem granulomatous disease that most commonly affects the lungs and skin, and can also affect eyes and lymph glands. We describe an unusual case of sarcoidosis presenting with hypercalcemia, causing diagnostic challenges. A 5year old boy was incidentally found to have asymptomatic hypercalcaemia during a routine clinic review for failure to thrive. Apart from a recent Influenza A infection, when he was found to have normal calcium levels and severe...

Background: Limited evidence exists regarding the effect of antenatal prednisolone (ANP) on neonatal adrenal function. Our regional neonatal unit screens these babies by measuring three random serum cortisol levels 8 h apart on day 3 of life. Adrenal function is considered adequate if two cortisol levels are >100 nmol/l. Those with inadequate random cortisol levels undergo a low-dose Synacthen test (LDST). Our survey of UK tertiary Paediatric Endocrinology centres revealed...